The unique setting of neonatal clinical pharmacology will be highlighted based on the hazards of simple extrapolation of maturational drug clearance when only based on adult metabolism propofol paracetamol second maturational trends are not at the same pace for all maturational processes. Neonatal clinical pharmacology and therapeutics covers the significant advances in clinical pharmacology and the principles of neonatal therapeutics this book is composed of 20 chapters that tackle various neonatal diseases and their corresponding therapeutic options. Clinical trial design in neonatal pharmacology effect of center differences with lessons from the pediatric oncology cooperative research experience c moran p b smith. The unique setting of neonatal clinical pharmacology will be highlighted based on the hazards of simple extrapolation of maturational drug clearance when only based on adult metabolism propofol paracetamol second maturational trends are not at the same pace for all maturational processes. Neonatal drug dosing needs to be based on the physiological characteristics of the newborn the pharmacokinetic parameters of the drug and has to take maturational aspects of drug disposition into account