Targeted delivery of anti cancer drug to a localised tumor site has shown to improve the effectiveness of treatment as it concentrates drug at their site of action and thus reducing side effects at other parts glioma is a type of tumor that starts in the glial cells of the brain or the spine glioblastoma multiforme also called glioblastoma is the most common and aggressive form of primary . Sp slip absorb plasma apolipoproteins a1 e and j consequently exposing receptor binding domain of apolipoproteins to achieve brain targeted delivery doxorubicin loaded sp slip sp slip dox show significant enhancement of brain distribution and anti brain cancer effect in comparison to doxorubicin loaded plain liposomes sp slip preserve functions of the absorbed human plasma apoe and the corona mediated targeting strategy works in sp modified plga nanoparticles the present study may . Brain targeted drug delivery systems a focus on nanotechnology and nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers the book discusses key points in the development of brain targeted drug delivery summarizes available strategies and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems as the brain is the most important organ in the human body and disorders of the central nervous . During the last years considerable effort was focused in the field of brain targeted drug delivery various more or less sophisticated approaches such as intracerebral delivery intracerebroventricular delivery intranasal delivery bbb disruption nanoparticles receptor mediated transport vector mediated transport or chimeric peptides cell penetrating peptides prodrugs and chemical delivery systems have been attempted these approaches may offer many intriguing possibilities . Brain targeted drug delivery to the brain is valuable in the diseases of brain alzheimers diseases meningitis brain abscess epilepsy multiple sclerosis neuromylitis optica sleeping